Folate is one of the cornerstone nutrients of human vitality. Also known as vitamin B9, it plays a critical role in DNA synthesis, cell division, and energy metabolism. It becomes especially relevant during life transitions such as fertility, pregnancy, and menopause. Yet not all folate is created equal. Many supplements still rely on synthetic folic acid, a form that requires conversion in the body, a step not everyone performs efficiently. Active folate (5-MTHF) offers a direct, reliable alternative.
The essentials
What it is: Folate (vitamin B9) is a water-soluble vitamin essential for DNA synthesis, methylation, red blood cell formation, and homocysteine regulation.
Why it matters: Adequate folate supports healthy cell growth and division and helps maintain balanced homocysteine, a biomarker linked to heart, brain, and reproductive health.
Life stage relevance: Folate requirements rise during phases of hormonal change, from preconception and pregnancy through menopause and midlife, when cellular resilience and energy metabolism are especially important.
Folate in foods – a natural reference point
Folate is naturally present in leafy greens, legumes, liver, and certain fruits. Examples include:
- Spinach (100 g raw): ~190 µg folate
- Asparagus (100 g cooked): ~150 µg folate
- Lentils (100 g cooked): ~180 µg folate
These foods are nutrient-rich, but folate is highly sensitive to cooking, storage, and processing. As a result, actual intake can be inconsistent, making supplementation a reliable way to maintain adequate levels during stages of increased demand.
What to look for in a folate formula
The form matters. Active folate in the form of 5-MTHF bypasses the body’s need for enzymatic conversion, making it directly usable and consistent across individuals — including those with common MTHFR genetic variations. This ensures that supplementation delivers what it promises, regardless of genetic background.
Equally important is synergy. Folate and vitamin B12 are natural biochemical partners, working together in DNA synthesis, red blood cell formation, and homocysteine metabolism. When provided in their active forms, 5-MTHF and methylcobalamin, they create a reliable and inclusive foundation for energy, mood balance, and cellular resilience. This partnership is particularly relevant during life stages shaped by hormonal change, such as pregnancy and menopause, when the demands on these pathways naturally increase.
Quatrefolic™ – The active folate with trusted science
Quatrefolic® is a fourth-generation active folate (6S-5-methyltetrahydrofolate glucosamine salt), developed by Gnosis by Lesaffre in Europe. Manufactured through advanced fermentation science, it offers superior solubility, stability, and consistency compared with traditional forms. It is produced under strict GMP standards.
Clinical data show Quatrefolic® effectively raises folate status, supports pregnancy health, and reduces plasma homocysteine. It has also been studied for its role in supporting mood and cognitive function. For those with MTHFR polymorphisms, Quatrefolic® provides a direct and inclusive solution.
Where to find it
Quatrefolic™ active folate is included in the Health Royals™ Peak performance formula, supplied at 200 µg per daily dose - equivalent to 100% of the general folate NRV.
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Disclaimer: This article is intended solely for general informational purposes. It does not provide medical advice, diagnosis, or treatment, nor should it be interpreted as making health claims. The content summarises ingredient characteristics based on publicly available research. Individual experiences may differ. For any questions regarding supplementation, nutrition, or personal health, please consult a qualified healthcare professional before making decisions.
