Folate in one glance
Folate is one of the cornerstone nutrients of human vitality. Also known as vitamin B9, it plays a critical role in DNA synthesis, cell division, and energy metabolism. It’s especially vital during life transitions like fertility, pregnancy, and menopause. Yet not all folate is created equal. Many supplements still rely on synthetic folic acid, a form that must be converted in the body, a step that isn’t efficient for everyone. Active folate (5-MTHF) offers a direct, reliable alternative.
The essentials
What it is: Folate (vitamin B9) is a water-soluble vitamin essential for DNA synthesis, methylation, red blood cell formation, and homocysteine regulation.
Where it lives: Naturally present in leafy greens, legumes, liver, and certain fruits. In supplements, it appears as synthetic folic acid or bioactive forms like 5-MTHF.
Why it matters: Folate supports healthy cell growth and division. It also helps regulate homocysteine, a key biomarker linked to heart, brain, and reproductive health. Folate needs increase during phases of hormonal shift, making it especially relevant from preconception through menopause and beyond.
Folate in foods – a natural reference point
Spinach (100 g raw): ~190 μg folate
Asparagus (100 g cooked): ~150 μg folate
Lentils (100 g cooked): ~180 μg folate
These are nutrient-rich choices, but folate is highly sensitive to cooking, storage, and processing. That makes supplementation a reliable way to maintain adequate intake, especially during stages of life when nutritional demands shift.
Three things to look for in a folate formula
- Active form (5-MTHF) – Bioavailable and ready to use, bypassing the need for metabolic conversion.
- Stability – A form that remains shelf-stable, resisting oxidation and humidity.
- Genetic inclusivity – Suitable for individuals with MTHFR variations, who may struggle to convert folic acid efficiently.
Smart synergy: Folate + Vitamin B12
Folate and B12 are biochemical partners. Together, they support DNA replication, red blood cell formation, and homocysteine metabolism. Using active folate alongside bioactive B12 (methylcobalamin) ensures both nutrients perform at their best. This is especially important for women navigating hormonal changes, as these vitamins influence mood, energy, and cellular resilience.
Quatrefolic®, our selected folate
What it is
Quatrefolic® is a patented glucosamine salt of (6S)-5-methyltetrahydrofolate, offering the body-ready form of folate with exceptional solubility and stability. Unlike folic acid, it does not require activation, ensuring consistent absorption across genetic types.
What the research shows
Clinical data show Quatrefolic® effectively raises folate status, supports pregnancy health, and reduces plasma homocysteine. It has also been studied for its role in supporting mood and cognitive function. For those with MTHFR polymorphisms, Quatrefolic® provides a direct and inclusive solution.
Why we selected it
Quatrefolic® sets a new benchmark in folate supplementation. Its high solubility, excellent stability, and immediate bioavailability make it the intelligent choice for modern, life-stage support. Our formula delivers 200 μg of active folate (5-MTHF) per daily dose, equal to 100% of the NRV*, provided in two softgels for optimal absorption and peace of mind.
References
[1] EFSA NDA Panel (2014). Scientific Opinion on health claims related to folate and normal blood formation, maternal tissue growth during pregnancy, homocysteine metabolism, psychological functions, immune system function and cell division.
[2] Quatrefolic® Scientific Dossier – (6S)-5-methyltetrahydrofolate glucosamine salt, bioavailability and stability data.
[3] Bailey SW, Ayling JE. (2009). The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake. PNAS.
[4] Clinical trials on Quatrefolic® bioavailability and homocysteine reduction, reported in the Quatrefolic® 360° ebook.
* Nutrient Reference Value. It is the daily amount of a vitamin or mineral set by the EU as sufficient for the average healthy adult. When a product states 100% NRV, it means one daily serving provides the full recommended daily intake. 👉 Keep in mind: NRVs are designed to prevent deficiencies across the general population. They are not always the same as the optimal intake for specific life stages, wellness goals or advanced nutrition.
📌 Disclaimer: This article is for informational and educational purposes only. It summarises clinical observations and authorised claim conditions for specific ingredients and does not make medical or therapeutic claims. It is not medical advice, nor is it intended to diagnose, treat, cure or prevent any disease. Individual results may vary. For personalised guidance on supplement use or health concerns, please consult a qualified healthcare professional.
